This volume contains a contribution written “by four hands” (the reference here is to the computer keyboard, not to a fountain pen; it is therefore written much like playing the piano, with two hands). It is a dialogue that took place over a period of about a year (between March 2013 and March 2014) on Facebook. These conversations demonstrate the possibility of an intellectually honest and constructive exchange (focused on ideas rather than people) even on a platform like Facebook, which, unfortunately, rarely lends itself to discussions of this nature. The topics covered are wide-ranging, spanning from physics to metaphysics, from scientific research to spirituality, from religion to faith... The richness of these reflections serves both as an inspiration and a reminder to approach the vast subject of life, its workings, and its possible meaning without resorting to facile simplifications.